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KMID : 0378019910340100055
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New Medical Journal
1991 Volume.34 No. 10 p.55 ~ p.61
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Immunoglobulin G Subclasses in Nephrotic Children
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Abstract
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The subject of abnormal immunity in idiopathic nephrotic syndr6me(!-,;S) has been known to .be an important role in pathogenesis or relapse of INS. For the efforts to understand the nature of immune dysfunction in INS, we tested their immunoglobulin levels and. IgG subclasses in serum and urine.
The results were as follows
1) When twenty INS patients were divided into relapsed and remitted groups. serum protein and albumin levels were low in relapsed group compared with remitted group. IgG. IgA, and IgE were also significantly low in relapsed group.
2) Urinary protein was increased in relapsed group, but urinary IgG concentration was statistically not significant although their level was higher than that of remitted group. The correlation coefficiency between urinary IgG concentration and serum IgG concentration was -0.157.
3) Of the results of IgG subclasses in their serum. the concentration of IgG1 was significantly low in relapsed group and that of IgG4 was significantly lower in steroid-responsive group than in steroid-resistant group. Urinary IgG subclasses was too low to conclude.
In conclusion, there were another factors. such as abnormal immunity. beside the urinary loss that could explain the low level of IgG and persistent low level of IgG after remitted. and this abnormal immune mechanism might be an important role in the pathogenesis of INS.
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KEYWORD
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